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For millennia, the traditional use of natural cannabinoids has provided empirical evidence that they may have considerably fewer adverse events than current synthetic pharmacological agents

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Notably, sustained BRD4 inhibition in transgenic mice induces multi-organ toxicity, manifesting as depletion of small intestinal stem cells, skin hyperplasia, and weight loss (240)

Elevated 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide concentrations in the household dust of farmers with recent occupational use