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The malate can then be decarboxylated to pyruvate via mitochondrial malic enzyme

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It has been shown that a nicotinamide-rich diet leads to an increased expression of sulfonylurea receptor SUR2, an ATP-binding subunit of ATP-sensitive potassium channels [22]

[63] using 16S rDNA and metabolomics sequencing, evaluated the changes in CD patients fecal microbial composition and metabolome characteristics