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This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis
doi:10.1161/CIRCULATIONAHA.109.904672 Rafeq Z, Roh JD, Guarino P, Kaufman J, Joseph J
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