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First, CO exhibits cytoprotective properties in vascular endothelial cells by inhibiting apoptosis, likely through activation of p38 mitogen-activated protein kinase (MAPK) signaling pathway (Brouard et al., 2000), decrease macrophage toll-like receptor (TLR) signaling with downstream activation of NF-kB (Wang et al., 2009) and inhibit expression of GM-CSF with probable alteration of macrophage differentiation (Sarady et al., 2002)

F.ArifM.TahaA

The peptide sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) remains stable in gastric acid, which distinguishes it from many other growth factors and healing compounds that degrade rapidly in the digestive system

However, these compounds have been confirmed to have significant neuroprotective and preventive activity in OIPN preclinical and clinical data [186, 187]

however, there are two isoforms present (Ero1 and Ero1) that seem to have similar functions but different tissue distribution (Cabibbo et al