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EspositoEMarianiPRavaniLContadoCVoltaMBidoSet al
In an experimental study performed in 5/6 nephrectomized normo- and hyperuricemic rats, febuxostat protected against renal damage, and prevented proteinuria, preserving vessel morphology and glomerular pressure, thus it prevents progression of CKD independently of its effect on UA.46 In the FOCUS47 extension study, 116 patients treated with febuxostat were followed for 5 years
Recent studies suggest that SIRT1 plays a key role in regulating ferroptosis through multiple mechanisms, including the activation of nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of antioxidant defense [9]
Debourdeau, P
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