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doi: 10.1016/j.antiviral.2014.07.010

In both cases, the atom must be willing to share its unbonded electron pair

ROS nano-scavengers can eliminate extracellular ROS in the tumor microenvironment to elicit an antitumor immunity and increase infiltration of T lymphocytes, resulting in highly potent antitumor effect in breast cancer 41

studied five copper complexes with bis-Schiff base ligands, of which complexes 1-3 are mononuclear and 4-5 are dinuclear([Cu (L 1)] (1), [Cu (L 2)] (2), [Cu (L 3)] (3), [Cu 2 (L 4) (OAc)] (4), and [Cu 2 (L 5) (HCOO)] (5) bearing the bis-Schiff base ligands of bis (5-chlorosalicylidene) -1,3-propanediamine (H 2 L 1), bis (5-chlorosalicylidene) -2-methyl-1,3-propanediamine (H 2 L 2), bis (5-bromosalicylidene) -2-methyl-1,3-propanediamine (H 2 L 3), bis (5-chlorosalicylidene) -2-hydroxyl-1,3-propanediamine (H 3 L 4), and bis (5-bromosalicylidene) -2-hydroxyl-1,3-propanediamine (H 3 L 5), respectively)

For ER-positive breast cancer patients, endocrine therapy is very beneficial, but some patients will develop endocrine therapy resistance