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Description
Higher doses of 5 mg and up are two to three times per week typically 20 days on the protocol followed by a break of 10 days
By activating AKT, selenium promotes the phosphorylation of downstream targets, such as endothelial nitric oxide synthase (eNOS) and glycogen synthase kinase-3 (GSK-3), leading to NO production and reducing apoptosis
Recent research in this area in the authors' laboratories was partly funded by the ANR-Genoplante project Redoxome (Orsay), ANR project Vulnoz (Orsay), and the EU Marie-Curie ITN COSI project (Orsay, Leeds)
Each of the approaches evaluated here has its own specific advantages and limitations, which are summarized in Table 1
GSH levels were normalized to protein content and expressed as nmol of GSH pre milligrams of protein
