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2025;118 doi: 10.1016/j.ebiom.2025.105836

This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (, )
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Trials administering oral or intravenous arginine and citrulline have reported improvements in uteroplacental hemodynamics and gestational blood-pressure control, without documenting teratogenicity or major maternal complications

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