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In vivo cognitive tests such as the Morris water maze and the passive step-down avoidance tests were performed with rats given oral doses of aqueous or 95% ethanolic extract of Schisandra chinensis (petroleum ether fraction) and showed that the extract could partially reverse the effects of decreasing activity of superoxide dismutase, catalase and the overall antioxidant effect induced by D-galactose, and to maintain normal levels of glutathione, malondialdehyde and nitric oxide in serum, prefrontal cortex, striatum, and hippocampus

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These studies highlight the growing potential of gene therapy not only as a means to address the core mechanisms of AMD, such as neovascularization and inflammation, but also as a strategy to combat oxidative stress, one of the key drivers of retinal damage in dry AMD

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