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Hepatology 43, S31S44 (2006)
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Importantly, ( R )-dHTC1 did not impact either cell line and KO of CRBN conferred resistance to ( S )-dHTC1 in MV4;11 cells, demonstrating on-target antiproliferative activity (Fig
Taurine stimulates HepG2 cells to express Insig-2a mRNA, retaining the INSIG2-SCAP-SREBP-1c complex in the ER, reducing the expression of hepatic lipogenic genes like Fas and SCD-1 regulated by SREBP1c [58]
