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Hyaluronic acid is vital for skin hydration and firmness

Age-related NAD+ decline impairs this critical DNA repair pathway CD38 balance: The ectoenzyme CD38 consumes NAD+ and increases with age, creating a vicious cycle of NAD+ depletion and immune dysregulation By restoring NAD+ levels, supplementation recalibrates multiple aging pathways simultaneously: improved DNA repair, enhanced mitochondrial biogenesis, restored epigenetic regulation, activated autophagy, and improved nutrient sensing

doi: 10.1001/jama.1961.73040330027011c

doi: 10.1016/j.autneu.2021.102829

It stimulates the TGF-beta pathway, which organizes collagen structure and promotes tissue contraction