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In several previously published studies, Pycnogenol was shown to improve circulation in small blood vessels in the body, like the very fine micro vessels in the fingertips or in the retinal capillaries of the eye (31, 46)

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Yang, Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy, Frontiers in Molecular Biosciences , vol