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Leishmania prevents the assembly of Nox2 complex in the vacuole membrane, inhibiting the generation of ROS and favoring its survival (43)

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In summary, our data provide new insights into the effects of tesofensine on weight loss and the underlying neuronal mechanisms, suggesting that tesofensine may be an effective treatment for obesity and that it may be a valuable adjunct to other appetite suppressants to prevent body weight rebound

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