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In the absence of validated protein, metabolite or genetic markers in CSF or blood, identifying patients most likely to benefit from ferroptosis-targeting therapies, assessing the treatment response or dose adjustment are difficult (9)

Identifying which neurons govern resilience mechanisms in AD may offer important insight towards targeted future therapies

Firstly, we discussed the epidemiology and various risk factors such as genetic mutations ( BRCA1/2, TP53, PTEN ), hormonal influences, several lifestyle risk factors (obesity, smoking, etc.), and environmental factors (chemical exposure, air pollutants, etc.)