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Glutathione Depletion: A Modern Epidemic Glutathione levels decline with age - typically by 1015% per decade after age 20 - and are further depleted by: *Chronic illness and autoimmune conditions *Environmental toxin exposure (heavy metals, pesticides) *Poor nutrition (insufficient cysteine, glycine, glutamate precursors) *Chronic psychological stress *Alcohol consumption *Certain medications (acetaminophen, chemotherapy agents) *Intense physical exercise without adequate recovery Given that thyroid disease prevalence increases with age and is associated with chronic immune activation, the parallel decline in glutathione levels is not coincidental - it is mechanistically significant

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Antioxidants such as vitamins C and E given during pregnancy have not demonstrated any significant positive effects [12,13]

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