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The possible mechanisms of TUDCA in suppressing apoptosis might involve in the activation of autophagy by increasing expression of autophagic related proteins (Beclin-1,LC3II/I) or inhibition of the ER stress via decreasing ER stress-related factors (IRE1, Chop, ATF6, Grp78 and Erdj4 ) [165,166,167,168]

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It has been shown that the multi-subunit -secretase complex (GS), an intra-membrane protease, reduces the CAR-T cell function via cleavage of the BCMA and subsequently secreting the soluble BCMA (sBCMA) into the circulation [129]

& Schaffer, J
