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& Herman, W
This is very difficult to test directly in practice because it requires direct comparison of the extent of tolerance produced by morphine with opioids that exhibit comparable intrinsic efficacy for G protein activation but much higher efficacy for endocytosis than morphine, while ensuring equivalent receptor stimulation and duration of action
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References Anderson, W, Mackay, I (2014) 'Fashioning the immunological self: The Biological Individuality of F
