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Oxidation of the reactive cysteine residues can result in a wide range of posttranslational modifications (e.g., S -glutathiolation, sulfenic acid, and disulfide formation), which can produce structural changes that are sufficient to alter protein function, stability, and subcellular localization (Rhee, 2006)
This manuscript provides deeper insight into the pathophysiology of PD, various drug delivery strategies to overcome BBB, and the potential role of nanoemulsions via the intranasal route

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