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Zappasodi, A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance

Redox-mediated inactivation of MGMT DNA repair through thiolation or nitrosylation of the active site cysteine145 sensitizes human gliomas to alkylating agents in vitro and in xenograft models

While remission is common, it is not known if systemic anti-inflammatory therapy decreases the risk of progressive pulmonary disease

doi: 10.1093/rheumatology/keaa401 100 LopezRGarciaLMartinezPFernandezCRuizSSanchezJet al

Given the important role of hypoxia in cancer survival and its well-known implications for treatment resistance, VitC-mediated regulation of HIF activity may provide another facet that is key for improving the treatment of solid tumours