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In further accordance, the tested agents (i) increase, rather than decrease, and water intake, (ii) block alcohol-induced hyperlocomotion and dopamine release in NAc which are parameters unaffected by aversion, and (iii) attenuates drug-related responses that are driven by reward rather than by malaise [for review see (115)]

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While 3D culturing of normal OSE remains unexplored for organoid construction, human oocytes have been mimicked in 3D structures derived from human embryonic stem cells (hESCs), showing meiotic entry and oocyte-like characteristics (Jung et al., 2017)