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Kohanski, M

Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

Baseline oxidative stress markers such as malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), and antioxidant enzyme activity predict responsiveness

Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect

Many cancers are already curable when detected early, and advanced cancers benefit from evidence-based treatments such as immunotherapy, targeted therapy, and personalised oncology care