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doi: 10.1007/s10989-020-10051-5

The prescribing information includes warnings about acute kidney injury, particularly in patients experiencing volume depletion

Similarly, in guinea pigs sensitized by milk ingestion, hyperexcitability in colonic submucosal AH neurons was associated with histamine release from mucosal mast cells acting on H 2 receptors, which couple to AC [114]

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It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)