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Mutations in ALDH3A2 are the molecular basis for SLS, an autosomal recessive disorder characterised by congenital ichthyosis, mental retardation, spasticity, ocular abnormalities and pruritus [26,27]

Superoxide anion radical (O 2 ), Hydrogen peroxide (H 2 O 2 ), and Hydroxyl ions (OH )] are produced in which different numbers of electrons have been transferred from O2 Absorption of radiant energy (UV rays , x-rays)- ionizing radiation can hydrolyze water into Hydroxyl (OH ) and hydrogen (H) free radicals Rapid bursts of Superoxide production occurs in the activated polymorphonuclear leukocytes during inflammation Nitric oxide NO is produced by endothelial cells, macrophages, neurons and other cell types NO can act as free radical and can also be converted into highly reactive peroxynitrite anion (ONOO ), NO 2 and NO 3 Enzymatic metabolism of exogenous chemicals and drugs generate free radicals e.g

In the culture of the CFMt1 strain, 640 mg L 1 acetate and 18 mg L 1 formate were also produced (Supplementary Table 3)

doi: 10.1093/biolre/ioy235 37 MaiZYangDWangDZhangJZhouQHanBet al

Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine