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cat no.), while non-targeting pool served as a negative control

Apoptosis in lung epithelial cells is critical in IPF pathogenesis, as heightened loss of these cells promotes fibroblast activation and remodeling

DD methylation analysis or plasma methionine/SAM/SAH panels reveal: methylation efficiency SAM/SAH ratio methionine sufficiency oxidative stress burden zinc/copper ratios presence of inflammation affecting the methylation cycle Treatment may include: methylcobalamin methylfolate (in appropriate cases) P5P TMG or betaine methionine support zinc correction gentle titration of SAMe Because undermethylation is closely linked to OCD-like presentations, supporting methylation improves OCD and undermethylation symptoms when paired with mitochondrial stabilization

The main clinical implications in this regard are summarized in Table 1

Gou, Y., et al