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Segmented filamentous bacteria ( SFB ) in the mouse gut promote the production of IL-17 and IFN- and play key roles in both osteoclast and osteoblast formation (221223), indicating that the GM modulates bone metabolism by altering the host immune status

This promotes the recruitment of TBK1, which phosphorylates the transcription factor IRF3, resulting in the production of IFN-I

doi: 10.3390/antiox10020201 5 RoychoudhurySChakrabortySChoudhuryAPDasAJhaNKSlamaPet al

Because of its unique resistance to enzymatic degradation, research suggests BPC-157 functions as a systemic signaling modulator across multiple interconnected cellular pathways (Sikiric et al., 2014)

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