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Subsequently, ent-kaurene is transformed into the intermediate GA12 through the actions of ent-kaurene oxidase (KO) and ent-kaurenoic acid oxidase (KAO) [69,70]

The absorption of UV irradiation directly by DNA can result in adducts between adjacent pyrimidine nucleotides, forming cyclobutane pyrimidine dimers (CPDs) and pyrimidine (64)pyrimidone photoproducts [(64)PPs] [34]

Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent

These effects are associated with increased expression of the cyclin-dependent kinase inhibitors (CDKNs) p21 and p27, which are negative cell cycle regulators (Pandey et al., 2010)

Additionally, it may promote the production of specific growth factors that aid tissue regeneration and repair