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Intranasal delivery represents the most significant methodological advancement because it bypasses hepatic first-pass metabolism entirely, but technique sensitivity (nasal cavity anatomy, administration volume, head positioning post-dose) introduces reproducibility challenges that subcutaneous injection avoids

Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) can be secreted from HFSCs by Wnt3a stimulation and has distinct extracellular functions

Peroxiredoxins (PRDXs) are antioxidant proteins containing catalytic cysteine residues that remove hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite 9

Currently, the exercise training regimen for DN therapy is still in the initial stage (Amaral et al., 2020)

Research has documented the ability of curcumin to inhibit several inflammatory cytokines