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At present, there are a large number of natural compounds-related studies registered on ClinicalTrials.gov, but most of the completed projects have not published their results, and most of the studies are in phase I/II clinical trials, with only a few studies in phase III

Finally, implementing treatment at different stages of treatment can also significantly influences the outcome, with particular emphasis on targeting LSCs during the initial complete remission (CR) phase when they exhibit greater homogeneity

Theanine attenuates memory impairments induced by klotho gene depletion in mice

doi: 10.1097/00000478-198203000-00004

It is common knowledge in this research field that bacteria, especially those with probiotic properties, can produce GABA because of their ability to express GAD genes