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J Biol Chem 277 : 1560015606 Hussein MR (2004) The TP53 tumor suppressor gene and melanoma tumorigenesis: Is there a relationship

IRS-2-expressing breast carcinoma cells are less invasive after treatment with an IGF-1R/IR small molecule inhibitor, which emphasizes the importance of upstream IGF-1R signaling through IRS-2 for the regulation of invasion [124]

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Nonetheless, some peptides/proteins have advanced through drug development, as shown in Table 4