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Key Points Oxidative stress is a key element in the pathophysiology of varicocele-related infertility and several mechanisms by which this operates have been studied but have not yet been fully described Although small quantities of reactive oxygen species (ROS) have important roles in sperm function, a disproportionate increase in ROS usually leads to oxidative stress Heat stress, hypoxia, reflux of adrenal and renal metabolites and hormonal disturbances have all been proposed as mechanisms to explain the pathophysiological effects of varicocele on testicular function Several intrinsic mechanisms are availableincluding the antioxidant enzymes catalase or superoxide dismutasethat counteract the actions of ROS

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However, the imbalance of metal ions, whether deficiency or excess, can lead to metabolic disorders, cell and tissue damage, weakened immunity and neurological dysfunction (Tian et al., 2024)

Unlike other antioxidants, Glutathione has the unique ability to recycle and recharge other antioxidants in our bodies, amplifying their effects and ensuring their continued functionality