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Thus, central GHR ablation likely impaired GH negative feedback, leading to increased body growth, especially in brain GHR KO mice

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10.1016/J.BRAINRESBULL.2021.05.028 [DOI] [PubMed] [Google Scholar] Anafi RC, Pellegrino R, Shockley KR, et al (2013) Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues

CJC-1295 solves this problem through structural modifications that resist enzymatic degradation (Teichman et al., J Clin Endocrinol Metab 2006)