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However, a study that included 97 women with high-frequency episodic migraine or chronic migraine and 146 healthy matched women found, although vitamin D levels were lower in migraine patients, they were not correlated with migraine frequency or with levels of calcitonin gene-related peptide (CGRP), measured on a non-migraine day, suggesting the relationship may not be causal (Haro 2025)

That is the regulatory backdrop

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Liang C., Lee J.S., Inn K.S., Gack M.U., Li Q., Roberts E.A., Vergne I., Deretic V., Feng P., Akazawa C., et al

MK-677 is a first-in-class ghrelin mimetic that increases both GH and IGF-1 levels without altering cortisol or testosterone, offering anabolic potential with minimal endocrine disruption. Murphy et al., Nature Reviews Drug Discovery How Does MK-677 Work

Vitamin B12 side effects Side effects from vitamin B12 supplementation are rare, and only occur with B12 injections, not oral supplementation, Allen says