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Med Cell Longev (2016) 2016:110

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The compound demonstrates blood-brain barrier (BBB) penetration efficiency approximately 1000-fold higher than comparable peptidesa critical factor in determining how frequently administration is required to maintain central nervous system concentrations adequate for receptor engagement

However, soluble (free) Gd 3+ concentration is likely to be unimportant in in vivo toxicity, and the kinetics of the exchange reaction with exogenous ligands are critical to delivering Gd 3+ to the tissue where it is rendered insoluble

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