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Description
AOD-9604 has more clinical data behind it, including human trials and FDA GRAS status

In C2C12 myotubes, NNMT inhibitor treatment produces concentration-dependent increases in NADH levels (50% higher at 30 M) and reduces NAD+/NADH ratios by 25-40%

In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]

Subcutaneous injection was chosen as 5A-1MQ specifically has poor oral bioavailability in mice, a phenomenon that does not occur in rats 26

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