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Antibiotic stewardship in dermatology: limiting antibiotic use in acne

Notably, the molecular events triggered by TMAO disrupt endothelial integrity by reducing the expression of tight junction proteins Zonula Occludens-2 (ZO-2) and Occludin (OCLN), while decreasing phosphorylated endothelial nitric oxide synthase (p-eNOS), thus increasing endothelial permeability and allowing LDL to enter and oxidize to ox-LDL [113, 114]

An automatic electronic vacuum pump was used to extract part of the air (the simulated altitude decompression speed of 2 m/s) in the cabin to simulate the plateau (altitude of 6000 m)

Am J Physiol Heart Circ Physiol (2014) 307:H60920

Predictive power was assessed using the 20% testing set and the ZOE PREDICT1 cohort as an additional validation dataset