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So, enzymes responsible for the constant NADPH production can be considered secondary antioxidants, as their misfunction could affect the whole ROS balance
Furthermore, it was determined that disulfiram/copper elicited antitumor activities against both nasopharyngeal cancer cells and cancer-associated fibroblasts through ROS/MAPK and p53-mediated ferroptosis pathways [106]
Consequently, this weakens the guts mucosal barrier and creates a vicious loop in colitis development (114)
M.HatwarM.PanzaJ.et al
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