vitamin b12 intramuscular injections Best Injection Site: Administering B12 Shots Where Should Vitamin B12 Be
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It has been reported several times that people who take B12 develop acne, she told Arielle Duhaime-Ross at The Verge

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This phenomenon is predominantly caused by cobalamin release during hepatic cytolysis and/or decreased cobalamin clearance by the affected liver

The Vitamin B12 and back pain connection is reflected within the scientific literature in terms of treatment of acute and chronic spinal conditions with the administration of B12 (often with other B vitamins)

Since there is no known hazardous threshold for vitamin B12, there is no upper limit