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Concurrently, targeting key lipid metabolic pathways offers innovative strategies to optimize existing therapies and overcome drug resistance

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The transcription factors XBP-1, ATF-4 and ATF-6 activate ERAD (Endoplasmic Reticulum Associated Degradation) components, genes regulating lipid synthesis, and upregulate ER resident chaperones, such as the Ig-binding protein BiP ortholog HSP-4

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Some people have dietary deficiencies of carnitine or cannot properly absorb this nutrient from foods that they eat