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The peptide's safety profile has been established through extensive animal studies and human clinical trials, with minimal side effects reported even during long-term administration protocols extending multiple years

Depending on the formulation, they may provide additional antioxidant or nutritional properties

In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

however, it was not judged to be clinically relevant

A., Thabit, M