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Aug 11 2024 Van Tin et al., Cells, doi:10.3390/cells13161331 Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-B Signaling In vitro study showing that the SARS-CoV-2 spike protein can activate cardiac fibroblasts through ACE2-dependent mechanisms, leading to cardiac fibrosis via the NLRP3 inflammasome and NF-B signaling pathways

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

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To account for the biologically relevant pharmacological range, we selected concentrations based on published applications of these inhibitors (Table 1), including lower and higher doses within those intervals

A conventional (and poorly sensitive) Lyme test was negative
