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doi: 10.1016/S0021-9258(18)94248-1

In animal reproduction studies, intravenous administration of pemetrexed to pregnant mice during the period of organogenesis was teratogenic, resulting in developmental delays and increased malformations at doses lower than the recommended human dose of 500 mg/m2

And if you overdose on copper, you can actually get toxicity from it

Research on intranasal peptide delivery indicates that molecules up to approximately 6000 Da can be absorbed, placing TB-500 within range but potentially at lower efficiency than smaller peptides like BPC-157

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