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Description
Further analyses revealed that treatment with IKE or AZD8055 alone only had very moderate effect on reducing phosphor 4EBP1 or GPX4 level in tumors, but their combination resulted in a potent suppression of phosphor 4EBP1 and GPX4 levels (Fig
Marti Navia A
, and Giusti M
Blood 140 (1), 73157316
Future directions should focus on developing tumor-specific copper ionophores and identifying predictive biomarkers to stratify patient populations likely to benefit from cuproptosis-based therapies
