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It is regulated by opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs) that catalyze the addition and removal of the acetyl group on lysine residues, respectively 108
How glutamate is synthesized: Glutamate is the most abundant free amino acid in the brain.[ref] As an excitatory amino acid, glutamate levels are strictly controlled by several mechanisms
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