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Why B12 Matters B12 deficiency becomes more common with age due to decreased absorption Many adults do not get enough B12 from diet alone Certain conditions (e.g., anemia, fatigue) may require supplementation Oral supplements are not always reliably absorbed Contact Details 2764 Aborn Road, San Jose, CA, USA

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In conclusion, in this review, we briefly describe the mitochondrial structure, summarize the specific regulatory mechanisms of the mitochondrial quality control system and the interaction between various pathways, and finally elaborate the research progress of mitochondrial biogenesis, mitophagy and mitochondrial dynamics in several common neurodegenerative diseases, in order to understand more about the mitochondrial quality control system and provide new research targets and ideas for the treatment of neurodegenerative diseases