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Furthermore, the GH and IGF system components are also locally produced by cancer cells and exert both autocrine and paracrine roles increasing the complexity of the global framework (2)
10.1038/s41586-020-2657-2 61 NapoliC.LermanL
The increased activity of HK and PFK not only enhances glycolysis in tumor cells but is also associated with the expression of immune checkpoint molecules, such as the upregulation of PD-L1
- Boosts immune function
7) In the endocrinopathies
