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For endometriosis patients who experience pain far out of proportion to visible disease, or who continue experiencing pain even after surgical excision of lesions, this central mechanism could explain why some report meaningful improvement on GLP-1 medications

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Recently, it was shown that mitochondria can be cleared upon PINK1-PARKIN mediated mitophagy in the absence of the mATG8-conjugation machinery and independent of lysosomal degradation via a process called autophagic secretion of mitochondria (ASM)