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Akin to adaptive SE-transcriptional programs-associated Ven resistance in solid tumors (Rusan et al., 2018), CDK7 inhibition can restore Ven-sensitivity in Ven-DTEP cells by repressing SE-driven expression of pro-survival genes and further reducing the expression of BCL2

Thats a long way of saying, if SIBO keeps coming back despite many rounds of intervention, chronic infections and/or mold exposure could be the missing link
Moreover, SF has been shown to modulate synaptic plasticity, a key mechanism for learning and memory

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