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J Am Chem Soc (2006) 128(24):77567

The pronounced and prolonged microglia ablation completely prevented cuprizone-induced demyelination with no substantial alterations to myelin ultrastructure [189]

Finally, 70 studies met the selection criteria for qualitative analysis (eTable 2 & 3 in the Supplement) and 47 studies for quantitative synthesis (eTable 4 in the Supplement and Fig
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Most research suggests that B12 supplementation is only beneficial for mental health when there is a true deficiency