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Extracellular mtDNA can act as a damage-associated molecular pattern (DAMP), triggering the activation of innate immune receptors such as toll-like receptors (TLRs) and inducing the production of type I interferons (IFNs) [131]
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doi:10.1021/bi902022n, PMID: 20070126 Yan Z, Garg SK, Kipnis J, Banerjee R (2009) Extracellular redox modulation by regulatory T cells
Immunity 56 , 25232541.e2528 (2023)
Where metabolism meets senescence: focus on endothelial cells
