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More importantly, there is strong experimental evidence that GC and CAs-mediated maladaptive changes may not only permanently affect the adult life of the conceptus but they can also be passed to the next generations through germ cells [33, 34]

Additionally, two-year safety data from the STEP 5 trial shows that while gastrointestinal events occurred in 82% of participants at some point during the study, most of these events were concentrated in the initial 6 months, with frequency and severity declining markedly in long-term treatment
